Indications for Use:

1. Infection with culture-proved organism

2. Empirical use in presumptive infection commonly caused by susceptible organisms normally requiring combination therapy.

1. Intra-abdominal sepsis

2. Endometritis

3. Pelvic inflammatory disease

4. Infections of lower respiratory tract

5. Other likely infections particularly involving Bacteroides

3. Prophylaxis in surgery for:

1. Elective colon surgery

2. Penetrating abdominal trauma

3. Cesarean-section (24 hours limit)

4. Vaginal hysterectomy

Dose:

1 - 2 grams every six hours with a maximum of 12 grams daily. Conform to MIC if cultured.

Possible development of third generation cephalosporin resistance in