| Long Surgical Procedures | ||||||
| Class | Drug | Intubation Dose† | Onset‡ | Duration§ | Repeat Bolus† | Average Infusion Rate†,¥ |
| (Trade Name, Manufacturer) | (mg/kg) | (min) | (min) | (mg/kg) | (range) | |
| Ultra-short-acting | Succinylcholine (various) | 0.6 (0.3-1.1) | 1 | 4-6 | 0.04-0.07 | 2.5-4.3 mg/min (0.5-10) |
| Short-acting | Mivacurium (Mivacron, Abbott) | 0.15-0.2 (or 0.25 in divided doses) | 1.5-3 | 15-25 | 0.1 | 5-7 mcg/kg/min (1-15) |
| Intermediate-acting | Atracurium (various) | 0.4-0.5 | 3-5 | 20-35 | 0.08-0.1 | 9-10 mcg/kg/min (2-15) |
| Cisatracurium (Nimbex, Abbott) | 0.15-0.2 | 1.5-2 | 55-61 | 0.03 | 1-2 mcg/kg/min (1-3) | |
| Rocuronium (Zemuron, Organon) | 0.6 (0.45-1.2) | 1-3 | 22-67 | 0.1-0.2 | 10-12 mcg/kg/min (4-16) | |
| Vecuronium (various) | 0.08-0.1 (up to 0.28) | 2.5-3 | 25-30 | 0.01-0.015 | 1 mcg/kg/min (0.8-1.2) | |
| Long-acting | Pancuronium (various) | 0.06-0.1 | 2-4 | 60-100 | 0.01 | ----------- |
| Tubocurarine (various) | 0.5-0.6 | 3-5 | 60-90 | 0.05-0.3 | 1-6 mcg/kg/min | |
*NMB agents should always be used in combination with sedative and/or anesthetic agents.
†Dosing information pertains to adults.
‡The onset of time to maximum block or time to good/excellent intubation conditions is dose dependent.
§Time from intubation dose administration to twitch recovery to 25% of control.
¥Infusion doses reflect initiation after bolus dose has begun to wear off.
Updated 01/23/2006
