March 21, 2019

Rupak Pathak, PhD

 

Assistant Professor

Department of Pharmaceutical Sciences
Phone: 501.603.1472
Fax: 501.686.6057
Office: BioMed II, Room: 411-2
Email: rpathak@uams.edu

Education & Training

  • MSc, North Bengal University, Darjeeling Govt. College, West Bengal, India
  • BEd, Jadavpur University, Kolkata, West Bengal, India
  • PhD in Radiation Biology, Kalyani University, Nadia, West Bengal, India
  • Postdoc in Radiation Biodosimetry, Armed Forces Radiobiology Research Institute, Bethesda, MD

Teaching Responsibilities

  • PhSc 7204 – Molecular Biology and Biotechnology (Course coordinator)
  • PSGP6112 – Radiation Biology for Graduate Students (Course coordinator)
  • PHSC 7105 – Pharmaceutics II

Research & Scholarly Interests

Dr. Pathak received his PhD in high-LET radiation biology in 2007 from Kalyani University, India. He completed his postdoctoral training in radiation biodosimetry from Armed Forces Radiobiology Research Institute (Bethesda, MD). Dr. Pathak then moved at University of Arkansas for Medical Sciences (UAMS, Little Rock, AR) in 2010 as a research instructor. In 20014, he was promoted to Research Assistant Professor at UAMS. He started his lab in 2016 as a tenure-track Assistant Professor at UAMS.
Dr. Pathak’s research focuses on understanding the mechanisms of normal tissue toxicity following radiation injury. His long-term goal is establishing therapies that restrict healthy tissue injury and controlling tumor growth simultaneously to make radiotherapy more safe and effective.

Honors & Awards

  • 1996: Awarded University Medal from North Bengal University (West Bengal, India) for securing 1st Class 2nd position in MSc with 74.9% marks.
  • 1999: UGC Funded University Project (UFUP) fellowship by UGC from Inter-University Accelerator Centre (New Delhi, India).
  • 2007: Award of Scholarship for Postdoctoral Research Associate, Henry M. Jackson Foundation, Rockville, Maryland, USA.
  • 2008: Awards of Resident Research Associateship by National Research Council (NRC) of the National Academies of USA.
  • 2009: Oral presentation in Mini-symposium of at the 55th Annual Meeting of Radiation Research Society in Savannah, Georgia, USA.
  • 2009: Scholars-in-Training (SIT) Travel Award, Georgia, USA, Radiation Research Society (RRS).
  • 2017: Early Career Investigator (ECI) Travel Award, the Grand Fiesta Americana Coral Beach resort in Cancun, Mexico, Radiation Research Society
  • 2018: 7th Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE) Young Investigator Travel award, Wardman Park Marriott, Washington DC, June 24-26, 2018.
  • 2018: Early Career Investigator (ECI) Travel Award, Historic Hilton Chicago Hotel, Chicago, September 23-26, 2018.

Membership

  • Regular member of Radiation Research Society
  • Regular member of Sigma Xi Scientific Research Society

Publications

  • Sadhukhan R, Leung JWC, Garg S, Krager KJ, Savenka AV, Basnakian AG, Pathak R*. Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose. Sci Rep. 2020 May 7;10(1):7734. [PMID: 32382091; PMCID: PMC7206069]
  • Binz RL, Tian E, Sadhukhan R, Zhou D, Hauer-Jensen M, Pathak R*. Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation. Sci Rep. 2019 Jul 22;9(1):10554. [PMID: 31332273; PMCID: PMC6646394]
  • Garg S, Sadhukhan R, Banerjee S, Savenka AV, Basnakian AG, McHargue V, Wang J, Pawar SA, Ghosh SP, Ware J, Hauer-Jensen M, Pathak R*. Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery. Antioxidants (Basel). 2019 Mar 6;8(3). pii: E57. [PMID: 30845647; PMCID: PMC6466604]
  • Pathak R*, Shah SK, Hauer-Jensen M. 2018. Therapeutic potential of natural plant products and their metabolites in preventing radiation enteropathy resulting from abdominal or pelvic irradiation. Int J Radiat Biol. 2018 Dec 7:1-43. [PMID: 30526224; PMCID: PMC6461490]
  • Wang J, Pathak R, Garg S, Hauer-Jensen M. Fibrinogen deficiency suppresses the development of early and delayed radiation enteropathy. World J Gastroenterol. 2017 Jul 14; 23 (26):4701-4711. [PMID: 28765691; PMCID: PMC5514635]
  • Pathak R*, Ghosh SP, Zhou D, Hauer-Jensen M. The Vitamin E analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM). Int J Mol Sci. 2016 Nov 18;17(11) [PMID: 27869747; PMCID: PMC5133932]
  • Pathak R*, Bachri A, Ghosh SP, Koturbash I, Boerma M, Binz RK, Sawyer JR, Hauer-Jensen M. The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage. Pharm Res. 2016 Sep;33(9):2117-25. [PMID: 27216753; PMCID: PMC4967083]Wu Y, Lee SH, Williamson EA, Reinert BL, Cho JH, Xia F, Jaiswal AS, Srinivasan G, Patel B, Brantley A, Zhou D, Shao L, Pathak R, Hauer-Jensen M, Singh S, Kong K, Wu X, Kim HS, Beissbarth T, Gaedcke J, Burma S, Nickoloff JA, Hromas RA. EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair. PLoS Genet. 2015 Dec 18;11(12):e1005675. [PMID: 26684013; PMCID: PMC4684289]

Curriculum Vitae