Department of Pharmaceutical Sciences
Education & Training
- Arkansas Tech University, B.S. Chemistry
- University of Arkansas for Medical Sciences College of Pharmacy, Pharm.D.
- University of Arkansas for Medical Sciences Graduate School, Ph.D. Pharmacology
- University of Arkansas for Medical Sciences, Dept. of Pharmacology/Toxicology, Postdoctoral Fellow
- PHSC 7201 Pharmacology I
Research & Scholarly Interests
My research interest is focused on learning the techniques and approaches that underscore hypothesis-driven basic and translational cardiovascular/lymphatic pharmacology research. The primary focus is the mechanisms of damage to the lymphatic system during cancer chemotherapy and developing therapeutic strategies to reduce this damage. The laboratory uses techniques such as tissue dissection, enzymatic cell isolation, flow cytometry, vascular functional studies, and gene and protein expression assays. The laboratory also employs both surgical techniques to measure lymph flow in vivo using high-speed optical imaging.
Another area of interest is the potential effects of cardiovascular drugs on lymphatic function. Hypertension has been associated with an increased risk of lymphedema in breast cancer patients. It is unclear whether this increased risk is due to the role of lymphatics in hypertension pathology or the medications used to treat hypertension. Thus we aim to study the effect of antihypertensive agents on lymphatic function and determine the contribution of antihypertensive agents to the development of lymphedema in cancer patients.
Stolarz AJ, Sarimollaoglu M, Marecki JC, Fletcher TW, Galanzha EI, Rhee SW, Zharov VS, Rusch NJ. Doxorubicin activates ryanodine receptors in rat lymphatic muscle cells to attenuate rhythmic contractions and lymph flow. Journal of Pharmacology and Experimental Therapeutics August 22, 2019,jpet.119.257592; DOI: https://doi.org/10.1124/jpet.119.257592. PMID: 31439806
Sarimollaoglu M, Stolarz AJ, Nedosekin DA, Garner BR, Fletcher TW, Galanzha EI, Rusch NJ, Zharov VP. High-speed microscopy for in vivo monitoring of lymph dynamics. J Biophotonics. 2018 Aug; 11(8):e201700126. DOI: 10.1002/jbio.201700126. PMCID: PMC6314807.
Stolarz AJ, Lakkad M, Klimberg VS, Painter JT. Calcium channel blocker and risk of lymphedema among breast cancer patients: nested case control study. Cancer Epidemiol Biomarkers Prev August 9 2019 DOI: 10.1158/1055-9965.EPI-19-0448. PMID: 31399477.
Stolarz AJ, Rusch NJ. Gender Differences in Cardiovascular Drugs. Cardiovasc Drugs Ther. 2015; 29(4): 403-410.
Stolarz AJ, Rusch NJ. Gender Differences in Cardiovascular Drugs. In: Mehta J., McSweeney J. (eds) Gender Differences in the Pathogenesis and Management of Heart Disease. Springer, Cham March 03 2018; https://doi.org/10.1007/978-3-319-71135-5_16