University of Arkansas for Medical Sciences Logo University of Arkansas for Medical Sciences
College of Pharmacy

Amit K. Tiwari Ph.D., DABT

Associate Dean of Research and Graduate Studies; Professor of Pharmaceutical Sciences
Biomedical Bldg II, Rm 140-2E
501-526-7388
atiwari@uams.edu
501-686-6057
 

Pharmaceutical Sciences

Education and Training

  • Postdoctoral Associate Mount Sinai School of Medicine, NY, 2013
  • Ph.D. in Pharmaceutical Sciences and Pharmacology St. John’s University, NY, 2011
  • M.S. in Pharmaceutical Sciences and Pharmacology St. John’s University, NY, 2008
  • B.S. in Pharmacy RamEesh Institute, U.P.T.U. University, 2005

Research and Scholarly Interests

  • Dr. Tiwari directs the Cancer and Systems Therapeutics (CAST) program at the University of Arkansas for Medical Sciences. CAST team is involved in a) developing effective, safe, and targeted anticancer therapeutics against multidrug-resistant cancers; b) designing, synthesizing and characterizing non-conventional forms of cell death inducers i.e. modulators of necroptosis, methuosis, and autophagy. CAST is also engaged in innovative drug delivery systems, natural products drug discovery, and chemical toxicity. CASTers are particularly interested in the identification of novel targets (single and multi-targets), synthesis and optimization of lead compounds, PK (ADME), PD (i.e. efficacy, model/assay developments, and mechanistic studies), drug-drug/herbal interactions, drug resistance, advanced toxicology assessments, and IP protection and commercialization.

Honors and Awards

SELECTED

  • Ambassador Award, Awarded by Govt. of Madhya Pradesh (MP, India) in collaboration with MP Council of Science and Technology, 2023
  • President’s Award for Excellence in Creative and Scholarly Activity, University of Toledo, OH, 2022
  •  Outstanding Research and Scholarship Award, University of Toledo, OH, 2022
  •  Distinguished Young Alumni Award, St. Johns University, NY, 2022
  •  Outstanding Advisor Award, University of Toledo, OH, 2021
  •  Distinguished Scientist Award, International Association of Pharmacy Professionals, 2021

Memberships

  • American Society of Pharmacol and Experim. Therapeutics (2019- Present)
  • The Rho Chi Society (2017- Present)
  • The Sigma Phi Sigma Society (2016- Present)
  • American Association of College of Pharmacy (2015- Present)
  • American Association of University Professors (2015- 2023)
  • American Association of Pharmaceutical Sciences (2012- 2013, 2023-Present)
  • American Association for the Advancement of Science (2011- 2014)
  • New York Academy of Sciences (2011- 2018)
  • American Cancer Society (2009- Present)
  • American Association for Cancer Research (2008-Present)

Publications

SELECTED PUBLICATIONS

  • Kang X, Jadhav S, Annaji M, Huang CH, Amin R, Shen J, Ashby CR Jr, Tiwari AK, Babu RJ, Chen P. Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems. Pharmaceutics. 2023 May 23;15(6):1567. doi: 10.3390/pharmaceutics15061567. PMID: 37376016
  • Zajac KK, Malla S, Babu RJ, Raman D, Tiwari AK. Ethnic disparities in the immune microenvironment of triple negative breast cancer and its role in therapeutic outcomes. Cancer Rep (Hoboken). 2023 Jan 12:e1779. doi: 10.1002/cnr2.1779. PMID: 36632988
  • Golonka RM, Yeoh BS, Saha P, Gohara A, Tummala R, Stepkowski S, Tiwari AK, Joe B, Gonzalez FJ, Gewirtz AT, Vijay-Kumar M. Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice. Hepatol Commun. 2023 May 23;7(6):e0166. doi: 10.1097/HC9.0000000000000166. eCollection 2023 Jun 1. PMID: 37219858
  • Al Saqr A, Annaji M, Poudel I, Aldawsari MF, Alrbyawi H, Mita N, Dhanasekaran M, Boddu SHS, Neupane R, Tiwari AK, Babu RJ. Topical Delivery of Diacetyl Boldine in a Microemulsion Formulation for Chemoprotection against Melanoma. Pharmaceutics 2023, 15, 901. https://doi.org/10.3390/pharmaceutics15030901
  • Deng LJ, Deng WQ, Fan SR, Chen MF, Qi M, Lyu WY, Qi Q, Tiwari AK, Chen JX, Zhang DM, Chen ZS. m6A modification: recent advances, anticancer targeted drug discovery and beyond. Mol Cancer. 2022 Feb 14;21(1):52. doi: 10.1186/s12943-022-01510-2. PMID: 35164788; PMCID: PMC8842557.
  • Abbott K, Salamat J, Flannery P, Chaudhury C, Chandran A, Vishveshwara S,; Mani S, Huang J, Tiwari AK and Pondugula S. Gefitinib Inhibits Rifampicin-Induced CYP3A4 Gene Expression in Human Hepatocytes. ACS Omega. 2022
  • Airbyawi H, Boddu, SHS, Poudel I, Annaji M, Mita N, Arnold RD, Tiwari AK, Babu RJ. Cardiolipin for enhanced cellular uptake and cytotoxicity of thermosensitive liposome-encapsulated daunorubicin toward breast cancer cell lines. International Journal of Molecular Sciences. 2022 Oct 4;23(19):11763. doi: 10.3390/ijms231911763. PMID: 36233061
  • Neupane R, Malla S, Abou-Dahech MS, Balaji S, Kumari S, Waikar DK, Moorthy NSHN, Trivedi P, Ashby CR, Chandrabose K, and Tiwari AK. Antiproliferative Efficacy of N-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine, DW-8, in Colon Cancer Cells is Mediated by Intrinsic Apoptosis. Molecules 2021, 26(15), 4417; https://doi.org/10.3390/molecules26154417
  • Hussein NA, Malla S, Pasternak MA, Terrero D, Brown NG, Ashby CR, Assaraf YG, Chen ZS and Tiwari AK. The role of endolysosomal trafficking in cancer drug resistance. Drug Resistance Updates. 2021 Jul;57:100769. doi: 10.1016/j.drup.2021.100769. PMID: 34217999
  • Sigdel I, Gupta N, Faizee F, Khare VM, Tiwari AK, Tang Y. “Biomimetic microfluidic platforms for the assessment of breast cancer metastasis”. Front Bioeng Biotechnol. 2021 Mar 11;9:633671. doi: 10.3389/fbioe.2021.633671. PMID: 33777909
  • Kumari S, Carmona A, Tiwari AK, Trippier PC. “Amide Bond Bioisosteres: Strategies, Synthesis and Successes”. J Med Chem 2020 Jul 20. doi: 10.1021/acs.jmedchem.0c00530. PMID: 32686940
  • Sridharan S, Howard CM, Tilley AMC, Subramaniyan B, Ruch R, Tiwari AK and Dayanidhi R. “Targeting of the eukaryotic translation initiation factor 4A against breast cancer stemness”. Frontiers in Oncology – Women Cancer, 2019 9, 1311; DOI: 10.3389/fonc.2019.01311. PMID: 31867270, PMCID: PMC6909344
  • Amawi H, Karthikeyan C, Pathak R, Hussein NA, Christman RM, Robey R, Ashby CR, Jr., Trivedi P, Malhotra A, Tiwari AK. Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress, and mitotic catastrophe. Eur J Med Chem. 2017 Jul 20;138:1053-1065. doi: 10.1016/j.ejmech.2017.07.028. PMID: 28759878

SELECTED PATENT APPLICATIONS

  • Raman D, Howard C, Nemunitis J, Brunicardi FC, Liu SH, and Tiwari AK. Targeting LASP1, elF4A1, e1F4B and CXCR4 with modulators And Combinations Thereof for Cancer Therapy (provisional D-2019-32, Ser. No. 62/807,075.) 2019
  • Tiwari AK, Hussein N, Ashby CR. Cariprazine and its analogues use in cancer therapy. (Application 60893-US-PSP/D2019-33, No. 62/934,638) 2019
  • Tiwari AK, Karthikeyan C, Nyinawabera, A. Necroptosis inducers and autophagy inhibitors in cancer therapy. (US patent application 2018, 60088-US-PSP/D2018-45).
  • Tiwari AK, Karthikeyan C, Amawi H, Erhardt P and Trivedi P. Materials and Methods Useful to Induce Cancer Cell Death Via Methuosis Or Autophagy Or A Combination Thereof. (US patent application 2017, 59593-US-PSP/D2018-15). Published 08-09-2022 – US11406626B2