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  1. University of Arkansas for Medical Sciences
  2. College of Pharmacy
  3. Team
  4. Nukhet Aykin-Burns, Ph.D.

Nukhet Aykin-Burns, Ph.D.

Associate Professor of Pharmaceutical Sciences
501-603-1375
NAykinBurns@uams.edu
501-686-6057
 

Member, Division of Radiation Health

Lab Phone: 501-603-1376

  • Dr. Aykin-Burns received her Ph.D. degree from the University of Missouri-Rolla (currently known as Missouri University of Science and Technology) focusing on antioxidant-based therapies in lead poisoning. She received postdoctoral training at the Free Radical and Radiation Biology Program (FRRBP), Department of Radiation Oncology at the University of Iowa.
  • Dr. Aykin-Burns is Associate Professor of Pharmaceutical Sciences at University of Arkansas for Medical Sciences (UAMS), member of the College of Pharmacy Division of Radiation Health.
  • Dr. Aykin-Burns’s research focuses on reactive oxygen species (ROS), mitochondrial function, radiation induced (IR and UV) normal tissue damage and wound healing as well as polychlorinated biphenyl (PCB) induced oxidative stress. Her laboratory also works on developing radioprotectors and radiomitigators for Acute Radiation Syndromes (ARS).
  • Secondary appointment at The University of Iowa, Human Toxicology Program

Recent Publications

Koss B, Shields BD, Taylor EM, Storey AJ, Byrum SD, Gies AJ, Washam CL, Choudhury SR, Hyun Ahn J, Uryu H, Williams JB, Krager KJ, Chiang TC, Mackintosh SG, Edmondson RD, Aykin-Burns N, Gajewski TF, Wang GG, Tackett AJ. Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion. Cancer Res. 2020 11 01; 80(21):4707-4719. PMID: 33004350. View in: PubMed

Kim HN, Ponte F, Nookaew I, Ucer Ozgurel S, Marques-Carvalho A, Iyer S, Warren A, Aykin-Burns N, Krager K, Sardao VA, Han L, de Cabo R, Zhao H, Jilka RL, Manolagas SC, Almeida M. Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors. Sci Rep. 2020 07 20; 10(1):11933. PMID: 32686739. View in: PubMed

Tascioglu Aliyev A, LoBianco F, Krager KJ, Aykin-Burns N. Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein. J Vis Exp. 2020 06 18; (160). PMID: 32628158. View in: PubMed

LoBianco FV, Krager KJ, Carter GS, Alam S, Yuan Y, Lavoie EG, Dranoff JA, Aykin-Burns N. The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury. Antioxidants (Basel). 2020 May 11; 9(5). PMID: 32403251. View in: PubMed

Aykin-Burns N, Pathak R, Boerma M, Kim T, Hauer-Jensen M. Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects. Semin Radiat Oncol. 2019 01; 29(1):55-61. PMID: 30573184. View in: PubMed

Alam S, Carter GS, Krager KJ, Li X, Lehmler HJ, Aykin-Burns N. PCB11 Metabolite, 3,3′-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3: Examining the Contribution of MnSOD. Antioxidants (Basel). 2018 Sep 15; 7(9). PMID: 30223548. View in: PubMed

Wang L, Fang B, Fujiwara T, Krager K, Gorantla A, Li C, Feng JQ, Jennings ML, Zhou J, Aykin-Burns N, Zhao H. Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo. J Biol Chem. 2018 06 15; 293(24):9248-9264. PMID: 29724825.  View in: PubMed

Nukala U, Thakkar S, Krager KJ, Breen PJ, Compadre CM, Aykin-Burns N. Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans). Antioxidants (Basel). 2018 Feb 23; 7(2). PMID: 29473853.  View in: PubMed

 

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Mailing Address: 4301 West Markham Street, Little Rock, AR 72205
Phone: (501) 686-7000
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